Wednesday, February 16, 2005

NF2 Research: Honing the Proteome

Honing the Proteome
by Eric Schoch

As many as 150,000 Americans, and countless thousands more people around the world, struggle with neurofibromatosis, which causes tumors to grow on nerve tissue. It's the most common disease caused by the mutation of a single gene and can leave people disfigured, in pain, blind, deaf, or struggling with malignancies.

Except for surgery to remove threatening tumors, there is no treatment, there is no cure.

Wade Clapp, associate professor of pediatrics and of microbiology and immunology, and his colleagues at the Indiana University School of Medicine are working to change that. One of their areas of focus is the mast cell, an immune system component that appears to stimulate the growth of the tumors by secreting protein messengers.

Read on

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