Teaching the deaf children to dance
http://cities.expressindia.com/fullstory.php?newsid=177127
Sarah's children - Nepali Times
Well, its about Life. Life - as I see it. And about NF2 which is an ardent part of my life.
DH News Service Jaipur:
A physically-challenged boy from Kuchaman city in Rajasthan has made his family proud by topping the Senior Secondary Examination in the Commerce category. Akshit Kheralka was declared the topper by the Rajasthan Board of Secondary Education in Ajmer on Saturday. He secured 90.92 per cent marks.
It was a double pleasure for Akshit and Noble Senior Secondary School, as his classmate Abhishek Jain stood second in the examination for Commerce. But for Akshit, it was indeed a great moment that will go a long way in boosting his morale and achieving his aim of becoming a management expert in the future.
Akshit was born without properly formed hands but he never let this handicap obstruct his progress. He never went to coaching centres for tuitions but achieved the first position with regular studies, his father Chetan Kheralka, a salt merchant said. He told Deccan Herald that one should never feel inferior whatever the disability.
What makes Akshit's success special is that he wrote the exam with his half-formed hand. He said he cannot write with great speed but was given some extra time that helped him perform better. Nearly 34,000 students had appeared for the examination. The chairman of Rajasthan Board of Secondary Education, Dr Bimal Prasad Agrawal said had he opted for another ‘writer’, he would not have been able to secure the first position.
Akshit had secured 9th position in the VIIIth Board examination and secured 89 per cent marks in the Secondary examination. His proud parents said, “We have always told him not to let his disability dishearten him.
Some links to research works related to NF2 from Genetics point of view:
(If you know of links that can be put up here, please suggest. You can leave them as comments)
Wallace Ip, Ph.D., University of Cincinnati College of Medicine, Ohio
NF2, an inherited disorder that affects 1 in 40,000 individuals, is characterized by the formation of bilateral schwannoma of the 8th cranial nerve and predisposition to other nervous system tumors. NF2 is caused by mutations in a tumor suppressor gene called merlin, a member of a family of proteins that bind to the structural support network in cells (known as the cytoskeleton). Recent work by Dr. Wallace Ip at the University of Cincinnati College of Medicine, a recipient of an FY02 NFRP Idea Award, provides new insight into merlin localization and function. Dr. Ip's group demonstrated that most merlin within cells is attached to specialized areas of the cell membrane called lipid rafts. His data also suggest that merlin activation is accompanied by dissociation of merlin-containing lipid rafts from the cytoskeleton. Merlin is the first tumor suppressor to be localized to lipid rafts, which contain a high concentration of signaling molecules that regulate cell growth. These findings suggest that the ability of merlin to disrupt growth-promoting signaling pathways originating from the cell membrane may be dependent on its association with the rafts. Future studies will examine whether mutant merlin proteins modeled after mutations known in NF2 patients are defective in lipid raft targeting and whether forced localization of the mutant proteins to lipid rafts can restore normal function. Dr. Ip's research may provide explanations for the loss of function associated with some merlin mutations and ultimately help investigators develop new therapeutics for the affected individuals.
Publications:
Stickney JT, Bacon WC, Rojas M, et al. 2004. Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer Research 64:2717-2724.
